The Anti-CDC16 Antibody (CAB3583) is a valuable tool for researchers studying the cell division cycle protein 16 (CDC16), a key regulator of the anaphase-promoting complex/cyclosome (APC/C) pathway. This polyclonal antibody, produced in rabbits, is highly specific to CDC16 and is validated for use in Western blot applications with human samples.CDC16 plays a crucial role in cell cycle regulation, specifically in the transition from metaphase to anaphase during cell division. Dysregulation of CDC16 has been implicated in various diseases, including cancer, making it a promising target for therapeutic interventions.
By targeting CDC16, researchers can gain insights into the molecular mechanisms underlying aberrant cell division and potential therapeutic strategies for cancer treatment.This antibody allows for the detection and analysis of CDC16 in different cell types, providing researchers with a versatile tool for investigating the role of CDC16 in various physiological and pathological processes. Its high reactivity and specificity make it an essential reagent for studies in cell biology, oncology, and drug development. Unlock the potential of CDC16 research with the reliable and validated Anti-CDC16 Antibody (CAB3583).
Product Name:
CDC16 Rabbit Monoclonal Antibody
SKU:
CAB3583
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human CDC16 (Q13042).
Cytoplasm, centrosome, cytoskeleton, microtubule organizing center, spindle.
Calculated MW:
72kDa
Observed MW:
72kDa
The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified.
Purification Method:
Affinity purification
Gene ID:
8881
Clone Number:
ARC2053
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from NIH/3T3 cells, using CDC16 Rabbit mAb (CAB3583) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
