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Anti-CD68 Antibody (CAB20555)

SKU:
CAB20555
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
La
ma
Sca
gp11
Lamp4
gp110
Scard1
$167 - $503
Frequently bought together:

Description

Anti-CD68 Antibody (CAB20555)

The Anti-CD68 Antibody (CAB20555) is a valuable tool for researchers studying CD68, a cell surface glycoprotein commonly used as a marker for macrophages and monocytes. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in applications such as immunohistochemistry and flow cytometry.CD68 is involved in various biological processes, including phagocytosis, inflammation, and antigen presentation. Its expression is commonly elevated in tissues undergoing immune responses, making it a key target for investigating immune-related diseases such as cancer, cardiovascular diseases, and neurodegenerative disorders.

By using the Anti-CD68 Antibody, researchers can effectively detect and quantify CD68 expression in various cell types and tissues, providing valuable insights into the role of macrophages and monocytes in immune responses and disease pathogenesis. This antibody is an essential tool for advancing our understanding of immune regulation and developing targeted therapies for a range of medical conditions.

Product Name:CD68 Rabbit pAb
Product Code:CAB20555
Size:50uL, 100uL
Synonyms:La, ma, Sca, gp11, Lamp4, gp110, Scard1
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of Mouse CD68.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Raji, RAW264.7
Immunogen:Recombinant protein of Mouse CD68.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:12514
Uniprot:P31996
Calculated MW:34kDa
Observed MW:80kDa
UniProt Protein Function:CD68: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. Belongs to the LAMP family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell surface; Membrane protein, integral

Cellular Component: membrane; lysosome; integral to membrane; plasma membrane; endosome

UniProt Code:P31996
NCBI GenInfo Identifier:399215
NCBI Gene ID:12514
NCBI Accession:P31996.1
UniProt Secondary Accession:P31996,O54688, O70321, Q3S4A9, Q5F2A8, Q9DD15,
UniProt Related Accession:P31996
Molecular Weight:33,844 Da
NCBI Full Name:Macrosialin
NCBI Synonym Full Names:CD68 antigen
NCBI Official Symbol:Cd68  
NCBI Official Synonym Symbols:Lamp4; gp110; Scard1  
NCBI Protein Information:macrosialin
UniProt Protein Name:Macrosialin
UniProt Synonym Protein Names:CD_antigen: CD68
Protein Family:Macrosialin
UniProt Gene Name:Cd68  
UniProt Entry Name:CD68_MOUSE

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