The Anti-CD48 Antibody (CAB4084) is a crucial tool for researchers studying CD48, a cell surface molecule involved in immune responses and signaling. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the CD48 protein, it enables precise detection and analysis in a wide range of cell types, making it an ideal choice for studies within the fields of immunology and cancer research.CD48, also known as the signaling lymphocytic activation molecule (SLAM), plays a vital role in modulating immune responses and interactions between immune cells.
Its involvement in immune regulation positions it as a promising target for investigations into various diseases, including cancer, autoimmune conditions, and inflammatory disorders. Comprehensive understanding of CD48's functions is pivotal for the development of therapeutic strategies that aim to manipulate immune responses effectively.
Product Name:
CD48 Rabbit Monoclonal Antibody
SKU:
CAB4084
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 27-220 of human CD48 (NP_001769.2).
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
962
Clone Number:
ARC53030
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using CD48 antibody (CAB4084) at 1:20000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
