The Anti-CD44 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0227) is a cutting-edge tool for researchers studying the CD44 cell surface molecule. This antibody, developed in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blotting applications. By binding specifically to the CD44 protein, this antibody enables precise detection and analysis in various cell types, making it an essential asset for immunology and cancer research studies.
CD44, a transmembrane glycoprotein, is known for its diverse roles in cell adhesion, migration, and signaling processes. Its involvement in cancer progression, stem cell function, and immune regulation highlights its importance as a target of investigation in various diseases. Understanding the functions and regulation of CD44 is crucial for advancing knowledge and developing potential therapeutic interventions in cancer and other pathological conditions.
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
