null

CD40 Rabbit Monoclonal Antibody (CAB20214)

SKU:
CAB20214
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CD40
Bp50
CDW40
TNFRSF5
p50
Research Area:
Immunology
€419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:CD40 Rabbit Monoclonal Antibody
SKU:CAB20214
Size:100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-193 of human CD40 (P25942).
Sequence:EPPT ACRE KQYL INSQ CCSL CQPG QKLV SDCT EFTE TECL PCGE SEFL DTWN RETH CHQH KYCD PNLG LRVQ QKGT SETD TICT CEEG WHCT SEAC ESCV LHRS CSPG FGVK QIAT GVSD TICE PCPV GFFS NVSS AFEK CHPW TSCE TKDL VVQQ AGTN KTDV VCGP QDRL R
Tested Applications:FC ELISA
Recommended Dilution:FC,1:50 - 1:200
Synonyms:p50; Bp50; CDW40; TNFRSF5; CD40
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:31kDa
Observed MW:Refer to figures

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Purification Method:Affinity purification
Gene ID:958
Clone Number:ARC5133-01
Storage Buffer:Store at 4℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% thimerosal,pH7.3.
Product ImageFlow cytometric analysis of CD40 Rabbit mAb Cocotail (1:100 dilution) in Daudi cells (Orange) compare to rabbit IgG Isotype control (Blue) and non-staining control (Red ).

Related Products