The CD3G Polyclonal Antibody (CAB4085) is a valuable tool for researchers studying CD3G, a key component of the T-cell receptor complex essential for T-cell activation and function. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the CD3G protein, this antibody facilitates the detection and analysis of CD3G in various cell types, making it an ideal choice for studies in immunology and cancer research.CD3G is a crucial protein involved in T-cell signaling and activation, playing a pivotal role in the adaptive immune response. Dysregulation of CD3G expression or function can have profound implications for immune function and has been implicated in various diseases, including autoimmune disorders and cancer.
Understanding the molecular mechanisms underlying CD3G activity is essential for developing targeted therapeutic strategies aimed at effectively modulating T-cell function in the context of these conditions.Overall, the CD3G Polyclonal Antibody (CAB4085) serves as a reliable tool for investigating the role of CD3G in immune response modulation and offers valuable insights into the mechanisms underlying T-cell activation and function. Its specificity and sensitivity make it a valuable asset for researchers aiming to unravel the complexities of T-cell biology and its implications for human health and disease.
Product Name:
CD3G Rabbit Monoclonal Antibody
SKU:
CAB4085
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 83-182 of human CD3G (P09693).
The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency.
Purification Method:
Affinity purification
Gene ID:
917
Clone Number:
ARC2105
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CD3G Rabbit mAb (CAB4085) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 120s.
