The Anti-CD3D Antibody (CAB9770) is a valuable tool for researchers studying CD3D, a cell surface glycoprotein that plays a key role in T cell activation and function. This polyclonal antibody, produced in rabbits, is highly specific to human CD3D and has been validated for use in various applications such as Western blot and immunofluorescence.CD3D is a critical component of the T cell receptor complex, essential for antigen recognition and signal transduction. Dysregulation of CD3D expression or function can lead to immune dysfunction and contribute to the development of autoimmune diseases or immune deficiencies.
By targeting CD3D with this specific antibody, researchers can better understand the role of T cells in immune responses and potentially develop new therapies for T cell-related disorders.Overall, the Anti-CD3D Antibody (CAB9770) is a valuable tool for researchers in immunology, oncology, and autoimmune disease research, allowing for the detection and analysis of CD3D expression in various cell types and tissues. Its high specificity and sensitivity make it an essential component of any study involving T cell biology and function.
Product Name:
CD3D Rabbit Monoclonal Antibody
SKU:
CAB9770
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 72-171 of human CD3D (P04234).
The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.
Purification Method:
Affinity purification
Gene ID:
915
Clone Number:
ARC1741
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from Jurkat cells, using CD3D Rabbit mAb (CAB9770) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
