The Anti-CD38 Polyclonal Antibody (CAB20215) is a valuable tool for researchers studying CD38, a cell surface protein involved in immune regulation and cell signaling pathways. This antibody, manufactured for high reactivity with human samples, is ideal for use in Western blot applications for the detection and analysis of CD38 protein expression in various cell types.CD38 is known to play a crucial role in immune response modulation, making it a key target for research on diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.
By understanding the function and expression of CD38, researchers can develop new insights into immune regulation and potentially develop therapeutic approaches for these conditions.
Product Name:
CD38 Rabbit Monoclonal Antibody
SKU:
CAB20215
Size:
100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 43-300 of human CD38 (P28907).
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
952
Clone Number:
ARC5131-01
Storage Buffer:
Store at 4℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,pH7.3.
Human peripheral blood lymphocytes stained with CD38 Rabbit mAb (10 μg/mL) plus FITC conjugated goat anti-rabbit IgG (Blue). Secondary antibody only staining (red) were used as a control.
