null

CD35/CR1 Rabbit Monoclonal Antibody (CAB3661)

SKU:
CAB3661
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
C3BR
C4BR
CD35
KN
Research Area:
Immunology
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:CD35/CR1 Rabbit Monoclonal Antibody
SKU:CAB3661
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1940-2039 of human CD35/CR1 (P17927).
Sequence:DGYT LEGS PWSQ CQAD DRWD PPLA KCTS RTHD ALIV GTLS GTIF FILL IIFL SWII LKHR KGNN AHEN PKEV AIHL HSQG GSSV HPRT LQTN EENS RVLP
Tested Applications:IHC-P IF/ICC ELISA
Recommended Dilution:IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:KN; C3BR; C4BR; CD35; CD35/CR1
Conjugate:Unconjugated
Cellular Localization:Membrane, Single-pass type I membrane protein.
Calculated MW:224kDa

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria.

Purification Method:Affinity purification
Gene ID:1378
Clone Number:ARC2065
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageImmunohistochemistry analysis of paraffin-embedded human tonsil using CD35/CR1 Rabbit mAb (CAB3661) at dilution of 1:50 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.

Related Products