The CD35/CR1 Monoclonal Antibody (CAB3661) is specifically designed for research involving CD35/CR1, an essential cell surface receptor involved in immune regulation and clearance of immune complexes. This antibody, produced and validated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for various research applications, including Western blotting and immunohistochemistry.CD35, also known as Complement Receptor 1 (CR1), plays a crucial role in the immune system by recognizing and clearing pathogens and immune complexes. Dysregulation of CD35/CR1 has been implicated in various autoimmune disorders, infections, and inflammatory conditions.
Therefore, studying the expression and function of CD35/CR1 using this antibody can provide valuable insights into immune response modulation and potential therapeutic targets for related diseases.This antibody enables precise detection and analysis of CD35/CR1 expression in different cell types and tissues, making it an invaluable tool for researchers in immunology, infectious diseases, and autoimmune disorders. By understanding the role of CD35/CR1 in immune regulation, researchers can develop better strategies for managing immune-related disorders and developing targeted therapies.
Product Name:
CD35/CR1 Rabbit Monoclonal Antibody
SKU:
CAB3661
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1940-2039 of human CD35/CR1 (P17927).
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria.
Purification Method:
Affinity purification
Gene ID:
1378
Clone Number:
ARC2065
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human tonsil using CD35/CR1 Rabbit mAb (CAB3661) at dilution of 1:50 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
