The Anti-CD31 (PECAM1) Antibody (CAB20478) is a valuable tool for research involving CD31, a cell surface molecule known as platelet endothelial cell adhesion molecule 1. This polyclonal antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in various immunology and vascular biology studies.CD31 is a key player in endothelial cell adhesion and migration, crucial for processes such as angiogenesis and inflammation. The antibody recognizes the CD31 protein, allowing for its detection and analysis in different cell types and tissues. Its validation for use in techniques like Western blot makes it a reliable tool for researchers studying vascular biology, angiogenesis, and immune responses.
Understanding the role of CD31 in endothelial function and immune cell interactions is essential for unraveling its involvement in diseases like atherosclerosis, cancer, and inflammatory disorders. The Anti-CD31 (PECAM1) Antibody (CAB20478) provides researchers with a precise and effective means of studying the function and expression of CD31, aiding in the development of potential therapies and treatments targeting this molecule.
Product Name:
CD31/PECAM1 Rabbit Polyclonal Antibody
SKU:
CAB20478
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 611-678 of rat CD31/PECAM1 (NP_113779.1).
cell surface, cytoplasm, external side of plasma membrane, extracellular space, plasma membrane
Calculated MW:
76kDa
Observed MW:
130kDa
Enables protein phosphatase binding activity. Involved in several processes, including cellular response to interferon-gamma; negative regulation of GTPase activity; and negative regulation of actin filament polymerization. Located in cell surface and ruffle. Used to study pulmonary hypertension. Biomarker of bacterial pneumonia; orchitis; and osteoarthritis. Human ortholog(s) of this gene implicated in coronary artery disease (multiple); lung non-small cell carcinoma; neuroblastoma; and psoriatic arthritis. Orthologous to human PECAM1 (platelet and endothelial cell adhesion molecule 1).
Purification Method:
Affinity purification
Gene ID:
29583
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CD31/PECAM1 antibody (CAB20478) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
