The Anti-CD160 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0228) is a cutting-edge research tool designed for the study of CD160, a cell surface protein involved in immune regulation and modulation. This antibody, generated using advanced recombinant technology, specifically targets the CD160 protein and is highly reactive with human samples, ensuring accurate and reliable results in Western blot applications.CD160 is known for its role in immune response modulation and has been linked to various diseases, including cancer and autoimmune disorders. By targeting CD160 with this high-quality monoclonal antibody, researchers can gain valuable insights into the function and activity of this protein in different cell types, making it an essential tool for studies in immunology and cancer research.
With its superior specificity and sensitivity, the Anti-CD160 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0228) is a valuable asset for scientists looking to unravel the mechanisms underlying immune regulation and develop potential therapies for diseases influenced by CD160 activity. This antibody opens up new avenues for research and discovery in the field of immune regulation and disease pathogenesis.
SKU:
HDAB0228
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC270
Synonyms:
BY55, NK1, NK28
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16 cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab CD8brightCD95 CD56 CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules.
