The Anti-CCR9 Antibody (CAB9698) is a high-quality polyclonal antibody designed for research involving the C-C chemokine receptor type 9 (CCR9). CCR9 is known to play a crucial role in the migration and homing of immune cells to the gut mucosa, making it a valuable target for studying immune responses in the gastrointestinal system.This antibody is raised in rabbits and has been validated for use in various applications, including Western blot and immunohistochemistry. Its high reactivity with human samples makes it ideal for detecting and analyzing CCR9 expression in different cell types, providing valuable insights into the role of this receptor in immune regulation.
CCR9 has been implicated in various diseases, including inflammatory bowel disease, colorectal cancer, and autoimmune disorders affecting the gut. By studying the expression and function of CCR9 using this antibody, researchers can gain a better understanding of the underlying mechanisms involved in these conditions and develop targeted therapies to modulate immune responses in the gut mucosa.Overall, the Anti-CCR9 Antibody (CAB9698) is a valuable tool for researchers interested in studying the role of CCR9 in immune regulation and gastrointestinal diseases, offering reliable and specific detection of this important receptor in experimental settings.
Product Name:
CCR9 Rabbit Monoclonal Antibody
SKU:
CAB9698
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CCR9 (NP_112477.1).
The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the beta chemokine receptor family. Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammation conditions. This gene is differentially expressed in T lymphocytes of the small intestine and colon, and its interaction with chemokine 25 contributes to intestinal intra-epithelial lymphocyte homing to the small intestine. This suggests a role for this gene in directing immune responses to different segments of the gastrointestinal tract. This gene and its exclusive ligand, chemokine 25, are overexpressed in a variety of malignant tumors and are closely associated with tumor proliferation, apoptosis, invasion, migration and drug resistance. This gene maps to the chemokine receptor gene cluster. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10803
Clone Number:
ARC1706
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CCR9 Rabbit mAb (CAB9698) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
