CCR5 Rabbit Polyclonal Antibody (CAB20261)
- SKU:
- CAB20261
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CKR5
- CCR-5
- CD195
- CKR-5
- CCCKR5
- CMKBR5
- IDDM22
- CC-CKR-5
Description
Product Name: | CCR5 Rabbit Polyclonal Antibody |
SKU: | CAB20261 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 246-345 of human CCR5 (NP_000570.1). |
Sequence: | LFWA PYNI VLLL NTFQ EFFG LNNC SSSN RLDQ AMQV TETL GMTH CCIN PIIY AFVG EKFR NYLL VFFQ KHIA KRFC KCCS IFQQ EAPE RASS VYTR STGE |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5; CCR5 |
Positive Sample: | Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | cell surface, cytoplasm, endosome, external side of plasma membrane, plasma membrane |
Calculated MW: | 41kDa |
Observed MW: | 41kDa |
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 1234 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |