The CCR2 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0285) is a valuable tool for researchers studying CCR2, a chemokine receptor involved in immune cell migration and inflammation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in a variety of applications, including Western blot and immunohistochemistry.CCR2 is known for its role in regulating the recruitment of monocytes and macrophages to sites of inflammation, making it a key player in various immune responses, including those involved in cancer progression, autoimmune diseases, and inflammatory disorders.
By targeting CCR2 with this monoclonal antibody, researchers can efficiently detect and analyze CCR2 protein expression in different cell types, advancing their understanding of its function in the immune system.The versatility and reliability of the CCR2 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0285) make it a valuable tool for investigations into the role of CCR2 in health and disease, offering new insights that may ultimately inform the development of innovative therapeutic strategies targeting CCR2-mediated pathways.
SKU:
HDAB0285
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC447
Synonyms:
CC-CKR-2, MCP-1-R, CD192
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3.
