The Anti-CCR1 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0291) is a powerful tool for researchers studying CCR1, a chemokine receptor involved in immune cell migration and activation. This antibody, produced using cutting-edge technology, is highly specific and sensitive for detecting CCR1 in human samples.With its superior performance in applications such as Western blot and immunohistochemistry, this antibody enables precise detection and analysis of CCR1 expression in various cell types and tissues. Its reliability and reproducibility make it an essential tool for studies in immunology, inflammation, and infectious diseases.
CCR1 is a key player in the regulation of immune responses, making it an attractive target for therapeutic interventions in conditions such as inflammatory disorders, autoimmune diseases, and cancer. By using the Anti-CCR1 Chimeric Recombinant Rabbit Monoclonal Antibody, researchers can gain valuable insights into the role of CCR1 in disease pathogenesis and develop novel treatment strategies targeting this receptor.
SKU:
HDAB0291
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC465
Synonyms:
CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]
