Caveolin-1 Rabbit Monoclonal Antibody (CAB19006)
- SKU:
- CAB19006
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | Caveolin-1 Rabbit Monoclonal Antibody |
SKU: | CAB19006 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human Caveolin-1 (NP_001744.2). |
Sequence: | MSGG KYVD SEGH LYTV PIRE QGNI YKPN NKAM ADEL SEKQ VYDA HTKE IDLV NRDP KHLN DDVV KIDF EDVI AEPE GTHS |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:2000 - 1:10000 IHC-P,1:50 - 1:200 |
Synonyms: | CGL3; PPH3; BSCL3; LCCNS; VIP21; MSTP085; Caveolin-1 |
Positive Sample: | HeLa cells,Mouse lung ,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Golgi apparatus membrane, Membrane, Membrane raft, Peripheral membrane protein, caveola. |
Calculated MW: | 17kDa/20kDa |
Observed MW: | 21kDa/24kDa |
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
Purification Method: | Affinity purification |
Gene ID: | 857 |
Clone Number: | ARC50848 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |