The Caveolin-1 Polyclonal Antibody (CAB19006) is a vital tool for researchers studying Caveolin-1, a key protein involved in cellular signaling pathways and membrane organization. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it a reliable choice for Western blot applications. By binding to Caveolin-1, this antibody enables precise detection and analysis of this critical protein in various cell types, making it ideal for investigations in cell biology, signal transduction, and cancer research.
Caveolin-1 is known for its role in regulating cholesterol metabolism, cell proliferation, and cell migration, making it a promising target for understanding diseases such as cancer, cardiovascular disease, and neurodegenerative disorders. The Caveolin-1 Polyclonal Antibody is a valuable tool for researchers aiming to elucidate the mechanisms underlying Caveolin-1's functions and potential therapeutic implications in various pathological conditions.
Product Name:
Caveolin-1 Rabbit Monoclonal Antibody
SKU:
CAB19006
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human Caveolin-1 (NP_001744.2).
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
Purification Method:
Affinity purification
Gene ID:
857
Clone Number:
ARC50848
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Caveolin-1 Rabbit mAb (CAB19006) at 1:10000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
