The Anti-CASP1 Antibody (CAB20470) is a highly specific tool for researchers studying caspase-1, an important enzyme involved in inflammatory responses and programmed cell death. This polyclonal antibody, produced in rabbits, is specifically designed for use in Western blot and immunohistochemistry applications with high reactivity towards human samples.Caspase-1, also known as interleukin-1 beta converting enzyme, is a key player in the inflammatory pathway, cleaving pro-inflammatory cytokines and initiating the inflammatory response. Dysregulation of caspase-1 activity has been implicated in several inflammatory diseases, making it a promising target for therapeutic interventions.
By utilizing the Anti-CASP1 Antibody, researchers can accurately assess caspase-1 levels in various cell types and tissues, providing valuable insights into the mechanisms of inflammation and potential targets for drug development. This antibody is essential for studies in immunology, inflammation, and inflammatory diseases, offering a reliable tool for advancing research in these fields.
Product Name:
CASP1 Rabbit Polyclonal Antibody
SKU:
CAB20470
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of mouse CASP1 (NP_033937.2).
Enables cysteine-type endopeptidase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-1 beta production; and protein autoprocessing. Acts upstream of or within several processes, including membrane hyperpolarization; mitochondrial depolarization; and positive regulation of interleukin-1 alpha production. Located in extracellular region. Part of IPAF inflammasome complex. Is expressed in knee joint and metanephros. Orthologous to human CASP1 (caspase 1).
Purification Method:
Affinity purification
Gene ID:
12362
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse testis, using CASP1 antibody (CAB20470) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
