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Anti-Casein Kinase 1 alpha (CSNK1A1) Antibody (CAB9308)

SKU:
CAB9308
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CK1
CK1a
CKIa
HEL-S-77p
HLCDGP1
PRO2975
Research Area:
Cell Cycle
€139 - €419
Frequently bought together:

Description

Anti-Casein Kinase 1 alpha (CSNK1A1) Antibody (CAB9308)

The Anti-Casein Kinase 1 Alpha (CSNK1A1) Antibody (CAB9308) is a valuable tool for research involving the CSNK1A1 protein, a key regulator of cellular signaling pathways. This polyclonal antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically targeting the CSNK1A1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in molecular biology, cell signaling, and cancer research.CSNK1A1, also known as casein kinase 1 alpha, plays a crucial role in diverse cellular processes such as cell proliferation, differentiation, and metabolism.

Its dysregulation has been implicated in various diseases including cancer, neurological disorders, and metabolic syndromes. Investigating the function of CSNK1A1 is essential for understanding its role in disease pathogenesis and identifying potential therapeutic targets for intervention.Overall, the Anti-Casein Kinase 1 Alpha (CSNK1A1) Antibody (CAB9308) is a valuable tool for researchers aiming to unravel the intricacies of cellular signaling pathways and explore the therapeutic potential of targeting CSNK1A1 in the treatment of various diseases.

Product Name:Casein Kinase 1 alpha (CSNK1A1) Rabbit mAb
Product Code:CAB9308
Size:20uL, 50uL, 100uL
Synonyms:CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Casein Kinase 1 alpha (Casein Kinase 1 alpha (CSNK1A1))
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, NIH/3T3, Jurkat, Mouse lung, Rat lung, Rat brain
Immunogen:A synthesized peptide derived from human Casein Kinase 1 alpha (Casein Kinase 1 alpha (CSNK1A1))
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1452
Uniprot:P48729
Cellular Location:Chromosome, Cytoplasm, Nucleus speckle, centromere, centrosome, cytoskeleton, kinetochore, microtubule organizing center
Calculated MW:35kDa
Observed MW:35kDa
UniProt Protein Function:CK1A: an ubiquitous protein kinase of the CK1 family. Participates in Wnt signaling. Phosphorylates beta catenin, marking it for beta-TRCp-mediated ubiquitinylation and proteasomal degradation.
UniProt Protein Details:

Protein type:Protein kinase, CK1; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CK1 group; CK1 family

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: beta-catenin destruction complex; centrosome; cytosol; keratin filament; membrane; mRNA cleavage and polyadenylation specificity factor complex; nuclear speck

Molecular Function:kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: cell surface receptor linked signal transduction; Golgi organization and biogenesis; intermediate filament cytoskeleton organization and biogenesis; peptidyl-serine phosphorylation; phagocytosis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; regulation of cell shape; Wnt receptor signaling pathway

UniProt Code:P48729
NCBI GenInfo Identifier:31077177
NCBI Gene ID:1452
NCBI Accession:P48729.2
UniProt Secondary Accession:P48729,Q4JJA0, Q5U046, Q5U047, Q6FGA2, Q71TU5, Q96HD2 Q9UDK3, D3DQG0, D3DQG1,
UniProt Related Accession:P48729
Molecular Weight:37,567 Da
NCBI Full Name:Casein kinase I isoform alpha
NCBI Synonym Full Names:casein kinase 1 alpha 1
NCBI Official Symbol:CSNK1A1  
NCBI Official Synonym Symbols:CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p  
NCBI Protein Information:casein kinase I isoform alpha
UniProt Protein Name:Casein kinase I isoform alpha
UniProt Synonym Protein Names:CK1
Protein Family:Casein kinase
UniProt Gene Name:CSNK1A1  
UniProt Entry Name:KC1A_HUMAN

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