The CAMKII Polyclonal Antibody (CAB0198) is a valuable tool for researchers studying CAMKII, a key enzyme involved in cellular signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been extensively validated for Western blot applications. By binding specifically to the CAMKII protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential reagent for investigations in neuroscience and cell biology.CAMKII, also known as calcium/calmodulin-dependent protein kinase II, plays a crucial role in synaptic plasticity and memory formation in the brain.
Dysregulation of CAMKII activity has been implicated in various neurological disorders, making it an attractive target for therapeutic intervention. By elucidating the functions of CAMKII, researchers can gain insights into the molecular mechanisms underlying learning and memory processes, paving the way for the development of novel treatments for cognitive disorders.
Product Name:
CaMKII Rabbit Monoclonal Antibody
SKU:
CAB0198
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human CaMKII (NP_741960.1).
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
816
Clone Number:
ARC1814
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using CaMKII Rabbit mAb (CAB0198) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
