The Anti-Calsequestrin-1 Antibody (CAB19640) is a valuable tool for researchers studying calcium regulation in cells. Calsequestrin-1 is a calcium-binding protein found in the sarcoplasmic reticulum of muscle cells, where it plays a crucial role in storing and releasing calcium ions during muscle contraction. This polyclonal antibody, generated in rabbits, is highly specific to human calsequestrin-1 and has been validated for use in Western blot applications.By binding to calsequestrin-1, this antibody allows for the detection and analysis of this important regulatory protein in various cell types.
Understanding the role of calsequestrin-1 in calcium homeostasis is essential for research into muscle function, cardiac physiology, and diseases related to calcium dysregulation. The Anti-Calsequestrin-1 Antibody is a valuable tool for investigating the molecular mechanisms underlying these processes and may lead to new insights into therapeutic targets for conditions such as heart failure and muscle disorders.
Product Name:
Calsequestrin 1 Rabbit Monoclonal Antibody
SKU:
CAB19640
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 100-200 of human Calsequestrin 1 (NP_001222.3).
This gene encodes the skeletal muscle specific member of the calsequestrin protein family. Calsequestrin functions as a luminal sarcoplasmic reticulum calcium sensor in both cardiac and skeletal muscle cells. This protein, also known as calmitine, functions as a calcium regulator in the mitochondria of skeletal muscle. This protein is absent in patients with Duchenne and Becker types of muscular dystrophy.
Purification Method:
Affinity purification
Gene ID:
844
Clone Number:
ARC2209
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat heart, using Calsequestrin 1 Rabbit mAb (CAB19640) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
