The Anti-Cadherin 16 Antibody (CAB19644) is a valuable tool for researchers studying Cadherin 16, a cell adhesion molecule important in cell-cell interactions and tissue organization. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to Cadherin 16, this antibody allows for the detection and analysis of this protein in a variety of cell types, making it ideal for investigations in developmental biology and cancer research.
Cadherin 16 is known for its involvement in the regulation of cell adhesion and signaling pathways, making it a key player in processes such as tissue morphogenesis and cell migration. Dysregulation of Cadherin 16 has been linked to various diseases, including cancer and developmental disorders. By studying the function of Cadherin 16 using this antibody, researchers can gain insights into its role in these conditions and explore potential therapeutic interventions targeting this molecule.
Product Name:
Cadherin 16 Rabbit Monoclonal Antibody
SKU:
CAB19644
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 50-180 of human Cadherin 16 (O75309).
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
1014
Clone Number:
ARC2212
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse kidney, using Cadherin 16 Rabbit mAb (CAB19644) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
