The BRMS1 Polyclonal Antibody (CAB0768) is a valuable tool for researchers studying BRMS1, a gene known for its role in metastasis suppression in cancer. This antibody, generated in rabbits, is highly specific for BRMS1 and is validated for use in Western blot applications. By binding to the BRMS1 protein, this antibody enables precise detection and analysis in various cell types, making it an ideal choice for studies in cancer biology and metastasis research.BRMS1 is a tumor suppressor gene that has been shown to inhibit the spread of cancer cells to secondary sites in the body.
Understanding the function and regulation of BRMS1 is essential for developing targeted therapies that can suppress metastasis and improve patient outcomes in various types of cancers. This antibody provides researchers with a reliable tool to investigate the mechanisms underlying BRMS1-mediated metastasis suppression, offering insights that could lead to the development of novel cancer treatments.
Product Name:
BRMS1 Rabbit Monoclonal Antibody
SKU:
CAB0768
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BRMS1 (Q9HCU9).
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
25855
Clone Number:
ARC2536
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from A549 cells, using BRMS1 Rabbit mAb (CAB0768) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
