The BRD4 Polyclonal Antibody (CAB18840) is a valuable tool for researchers studying the BRD4 protein, a key regulator of gene expression and cell growth. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By targeting the BRD4 protein, this antibody enables precise detection and analysis in various cell types, making it an ideal choice for studies in cancer research, epigenetics, and drug discovery.BRD4 is known for its involvement in promoting cell proliferation and survival, making it a potential target for cancer therapy.
By understanding the role of BRD4 in gene regulation, researchers can gain insights into how to disrupt cancer cell growth and survival. Additionally, targeting BRD4 with small molecule inhibitors has shown promise in treating various types of cancer and inflammatory diseases.Overall, the BRD4 Polyclonal Antibody (CAB18840) is a valuable tool for researchers seeking to uncover the roles and therapeutic potential of the BRD4 protein in various disease states. Its high specificity and sensitivity make it an indispensable reagent for studying BRD4 function in both normal and diseased cells.
Product Name:
BRD4 Rabbit Polyclonal Antibody
SKU:
CAB18840
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 700-794 of human BRD4 (NP_001317313.1).
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
23476
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using BRD4 Rabbit pAb (CAB18840) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
