The BMP4 Polyclonal Antibody (CAB21065) is a valuable tool for researchers studying bone morphogenetic protein 4 (BMP4), a crucial signaling molecule involved in various cellular processes such as embryonic development, tissue regeneration, and stem cell differentiation. Raised in rabbits, this antibody is highly specific and reactive with human samples, making it ideal for use in Western blotting and immunohistochemistry applications.BMP4 plays a key role in skeletal and neural development, making it a target of interest in studies related to bone formation, cartilage development, and neural patterning. By detecting and analyzing BMP4 expression in different cell types and tissues, researchers can gain insights into its function and signaling pathways, paving the way for new therapeutic approaches in regenerative medicine, musculoskeletal disorders, and neurodevelopmental diseases.
With its high specificity and sensitivity, the BMP4 Polyclonal Antibody (CAB21065) is a reliable tool for investigating the role of BMP4 in various biological processes and disease states. Its validation for use in multiple research applications makes it a valuable asset for scientists working in the fields of developmental biology, regenerative medicine, and tissue engineering.
Product Name:
BMP4 Monoclonal Antibody
SKU:
CAB21065
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human BMP4 (NP_001193.2).
Secreted, Extracellular matrix, Extracellular space
Calculated MW:
47kDa
Observed MW:
47kDa
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers.
Purification Method:
Affinity purification
Gene ID:
652
Clone Number:
ARC52124
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using BMP4 antibody (CAB21065) at1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Negative control (NC): U-937Exposure time: 90s.
