The Anti-Beta Glucuronidase (GUSB) Antibody (CAB19248) is a valuable tool for researchers studying GUSB, an enzyme involved in the breakdown of complex carbohydrates. The antibody, produced in rabbits, has high specificity towards human samples and is validated for use in applications such as immunohistochemistry and ELISA.GUSB plays a vital role in the lysosomal degradation of glycosaminoglycans and its deficiency is associated with the rare genetic disorder, mucopolysaccharidosis. Research involving GUSB is essential for understanding the pathophysiology of diseases related to glycosaminoglycan metabolism and developing potential therapeutic interventions.
The Anti-Beta Glucuronidase Antibody enables the detection and quantification of GUSB in various biological samples, making it a valuable tool for studies in lysosomal storage disorders, enzyme replacement therapy, and drug development. Researchers can rely on this antibody to accurately assess GUSB expression levels and investigate its role in disease progression and treatment response.
This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.
Purification Method:
Affinity purification
Gene ID:
2990
Clone Number:
ARC2408
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using beta glucuronidase (beta glucuronidase (GUSB)) antibody (CAB19248) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
