The Anti-BCMA Biotinylated Recombinant Rabbit Monoclonal Antibody (HDAB0218) is a valuable tool for researchers studying B-cell maturation antigen (BCMA), a cell surface receptor involved in the survival and proliferation of multiple myeloma cells. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human BCMA protein, making it suitable for various applications such as immunohistochemistry and flow cytometry.BCMA is a promising therapeutic target in the treatment of multiple myeloma, a type of blood cancer that affects plasma cells.
By targeting BCMA, researchers aim to disrupt the signaling pathways that promote tumor growth and survival, leading to potential new treatments for this incurable disease. The Anti-BCMA Biotinylated Recombinant Rabbit Monoclonal Antibody offers researchers a reliable tool for investigating BCMA expression levels and distribution in cancer cells, advancing our understanding of the disease and potential treatment strategies.
SKU:
HDAB0218
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM4
Synonyms:
TNFRSF17
Applications:
ELISA, Flow Cyt
Recommended Dilution:
Flow Cyt 1:100; IP 1:30
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
