The Anti-ATP1B3 Antibody (CAB19637) is a highly specific and sensitive tool for studying the ATP1B3 protein, a critical component of the Na+/K+-ATPase complex involved in maintaining cell membrane potential and ion transport. This polyclonal antibody, produced in rabbits, is suitable for various research applications, including Western blot, immunofluorescence, and immunohistochemistry.ATP1B3, a subunit of the Na+/K+-ATPase pump, plays a crucial role in maintaining cellular homeostasis and regulating cell signaling pathways. Dysregulation of ATP1B3 expression or function has been implicated in various diseases, including neurological disorders, cardiovascular diseases, and cancer.
The Anti-ATP1B3 Antibody enables researchers to investigate the role of ATP1B3 in these pathologies and explore potential therapeutic strategies targeting this protein.With its high specificity and reactivity with human samples, the Anti-ATP1B3 Antibody is a valuable tool for researchers in the fields of cell biology, neuroscience, and cancer biology. By enabling the detection and analysis of ATP1B3 in various cell types and tissues, this antibody facilitates a deeper understanding of the physiological and pathological functions of the Na+/K+-ATPase complex.
Product Name:
ATP1B3 Rabbit Monoclonal Antibody
SKU:
CAB19637
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 180-279 of human ATP1B3 (P54709).
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2.
Purification Method:
Affinity purification
Gene ID:
483
Clone Number:
ARC2205
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using ATP1B3 Rabbit mAb (CAB19637) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
