The Anti-ATP1A2 Antibody (CAB19278) is a valuable tool for researchers studying ATP1A2, a key protein involved in ion transportation and neural communication. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting. By targeting the ATP1A2 protein, this antibody enables the precise detection and analysis of ATP1A2 expression in different cell types, making it an ideal choice for studies in neuroscience and neurology.
ATP1A2, a member of the Na+/K+ ATPase family, is essential for maintaining the electrochemical gradient across cell membranes, particularly in neurons. Mutations in ATP1A2 have been linked to neurological disorders such as familial hemiplegic migraine, highlighting the significance of this protein in brain function. Research on ATP1A2 can provide insights into the mechanisms underlying neurological diseases and may lead to the development of novel therapeutic strategies aimed at targeting ion transport dysfunction.
Product Name:
ATP1A2 Rabbit Monoclonal Antibody
SKU:
CAB19278
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ATP1A2 (P50993).
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood.
Purification Method:
Affinity purification
Gene ID:
477
Clone Number:
ARC2458
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ATP1A2 antibody (CAB19278) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
