The Anti-AT1R/AGTR1 Antibody (CAB4140) is a valuable tool for researchers studying the angiotensin II receptor type 1 (AT1R/AGTR1) protein, which plays a critical role in the renin-angiotensin system and is involved in regulating blood pressure and fluid balance. This polyclonal antibody, produced in rabbits, is highly specific to human AT1R/AGTR1 samples, making it ideal for Western blot applications.The AT1R/AGTR1 protein is a key target for drug development in the treatment of cardiovascular diseases, hypertension, and kidney disorders.
By targeting this receptor, researchers can better understand its role in these conditions and potentially develop new therapies to modulate its activity.With its high reactivity and specificity, the Anti-AT1R/AGTR1 Antibody (CAB4140) enables precise detection and analysis of AT1R/AGTR1 protein levels in various cell types, providing valuable insights for drug discovery and preclinical research. Invest in this antibody to advance your studies in cardiovascular research and drug development.
Product Name:
AGTR1 Rabbit Monoclonal Antibody
SKU:
CAB4140
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human AT1R/AGTR1 (P30556).
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
185
Clone Number:
ARC0905
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of A-549 cells, using AT1R/AGTR1 antibody (CAB4140) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
