The Anti-ASGR1 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0336) is a cutting-edge tool for researchers studying ASGR1, a cell surface receptor with implications in liver function and metabolic diseases. This antibody, developed using innovative chimeric technology, offers high specificity and sensitivity in detecting ASGR1 in various sample types, particularly in Western blot applications. ASGR1, also known as asialoglycoprotein receptor 1, is involved in the clearance of glycoproteins from circulation, making it a key player in liver physiology and pathology.
Dysregulation of ASGR1 has been linked to liver diseases and metabolic disorders, highlighting its potential as a therapeutic target. By targeting ASGR1 with this advanced monoclonal antibody, researchers can gain insights into the role of ASGR1 in liver function, metabolic disorders, and other related conditions. This antibody opens up new possibilities for exploring ASGR1's functions and developing targeted therapies for ASGR1-related diseases.
SKU:
HDAB0336
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC688
Synonyms:
ASGPR; ASGPR1; CLEC4H1; HL-1
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
