The Anti-Aromatase (CYP19A1) Antibody (CAB12238) is a valuable tool for researchers studying aromatase, an enzyme involved in the biosynthesis of estrogen. This polyclonal antibody, raised in rabbits, is highly specific to human aromatase and has been validated for use in various applications, including Western blotting.Aromatase (CYP19A1) plays a crucial role in the conversion of androgens to estrogens, making it a key player in hormone regulation and various physiological processes. Dysregulation of aromatase activity has been linked to conditions such as breast cancer, endometriosis, and infertility, making it an attractive target for therapeutic intervention.
By utilizing the Anti-Aromatase (CYP19A1) Antibody (CAB12238), researchers can effectively detect and analyze aromatase expression in different cell types, advancing our understanding of its role in health and disease. This antibody is a valuable tool for studies in endocrinology, reproductive biology, and cancer research, providing researchers with a reliable means to investigate the complex functions of aromatase in various biological contexts.
Product Name:
Aromatase Rabbit Monoclonal Antibody
SKU:
CAB12238
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Aromatase (CYP19A1) (P11511).
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities.
Purification Method:
Affinity purification
Gene ID:
1588
Clone Number:
ARC0635
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from U-87MG cells, using Aromatase (CYP19A1) Rabbit mAb (CAB12238) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
