The Anti-ARID1A Antibody (CAB19570) is a valuable tool for researchers studying ARID1A, a key protein involved in chromatin remodeling and gene expression regulation. This polyclonal antibody, produced in rabbits, is highly specific for ARID1A in human samples and is optimized for use in Western blot applications. By binding to ARID1A, this antibody enables accurate detection and analysis of the protein in a variety of cell types, making it an essential reagent for studies in cancer biology and epigenetics.ARID1A is known to play a crucial role in controlling gene expression and maintaining genomic stability, making it a significant factor in tumor development and progression.
Dysregulation of ARID1A has been implicated in various cancers, making it a promising target for therapeutic interventions. Understanding the function of ARID1A is essential for developing targeted therapies that can exploit its role in cancer progression and potentially improve patient outcomes.Overall, the Anti-ARID1A Antibody (CAB19570) offers researchers a reliable tool for studying the functions of ARID1A in cancer and beyond, providing valuable insights into the mechanisms underlying disease and potential therapeutic strategies.
Product Name:
ARID1A Rabbit Monoclonal Antibody
SKU:
CAB19570
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1204-1314 of human ARID1A (O14497).
This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8289
Clone Number:
ARC2177
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from PC-3 cells, using ARID1A Rabbit mAb (CAB19570) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
