Based on the information provided in the URL, I can help you with a product description for the Anti-ApoER2 (LRP8) Antibody (CAB9747).The Anti-ApoER2 (LRP8) Polyclonal Antibody (CAB9747) is a valuable tool for researchers studying the ApoER2 protein, also known as low-density lipoprotein receptor-related protein 8 (LRP8). This antibody is produced in rabbits and has a high reactivity specifically with human samples. It has been validated for use in Western blot applications, allowing for precise detection and analysis of the ApoER2 protein in various cell types.ApoER2 (LRP8) is a critical component in neuronal development and function, as well as in lipid metabolism. Its involvement in signaling pathways related to neuronal plasticity and synaptic transmission makes it an important target for research in neuroscience and neurodegenerative diseases.
By using the Anti-ApoER2 (LRP8) Antibody, researchers can gain valuable insights into the mechanisms underlying these processes and potentially discover new therapeutic avenues for neurological disorders.Overall, the Anti-ApoER2 (LRP8) Polyclonal Antibody (CAB9747) is a reliable tool for investigating the role of ApoER2 in various biological processes, offering researchers the opportunity to advance their understanding of neurobiology and potentially develop targeted treatments for neurological conditions.
Product Name:
ApoER2/LRP8 Rabbit mAb
Product Code:
CAB9747
Size:
20uL, 50uL, 100uL
Synonyms:
APOER2, HSZ75190, LRP-8, MCI1
Applications:
WB
Reactivity:
Human, Mouse, Rat
Host Species:
Rabbit
Immunogen:
A synthesized peptide derived from human ApoER2/LRP8
Applications:
WB
Recommended Dilutions:
WB 1:500 - 1:2000
Reactivity:
Human, Mouse, Rat
Positive Samples:
U-87MG, Mouse testis, Rat testis
Immunogen:
A synthesized peptide derived from human ApoER2/LRP8
Purification Method:
Affinity purification
Storage:
Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:
IgG
Sequence:
Email for sequence
Gene ID:
7804
Uniprot:
Q14114
Cellular Location:
Cell membrane, Secreted, Single-pass type I membrane protein
Calculated MW:
106kDa
Observed MW:
100-106kDa
UniProt Protein Function:
Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.
NCBI Summary:
This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]
