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ANK3 Rabbit Polyclonal Antibody (CAB20299)

SKU:
CAB20299
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MRT37
ANKYRIN-G
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:ANK3 Rabbit Polyclonal Antibody
SKU:CAB20299
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 833-977 of human ANK3 (NP_066267.2).
Sequence:KMNV PETM NEVL DMSD DEVR KANA PEML SDGE YISD VEEG EDAM TGDT DKYL GPQD LKEL GDDS LPAE GYMG FSLG ARSA SLRS FSSD RSYT LNRS SYAR DSMM IEEL LVPS KEQH LTFT REFD SDSL RHYS WAAD TLDN VNLV S
Tested Applications:IF/ICC ELISA
Recommended Dilution:IF/ICC,1:50 - 1:200
Synonyms:MRT37; ANKYRIN-G; ANK3
Conjugate:Unconjugated
Cellular Localization:basal plasma membrane, basolateral plasma membrane, cytosol, dendrite, endoplasmic reticulum, Golgi apparatus, lateral plasma membrane, lysosome, neuromuscular junction, neuron projection, plasma membrane, postsynaptic membrane, spectrin-associated cytoskeleton, T-tubule, Z disc
Calculated MW:480kDa
Observed MW:Refer to figures

Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.

Purification Method:Affinity purification
Gene ID:288
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageImmunofluorescence analysis of SH-SY5Y cells using ANK3 Rabbit pAb (CAB20299) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.

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