The ANK3 Polyclonal Antibody (CAB20299) is a valuable tool for researchers studying ANK3, a key protein involved in neuronal development and function. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the ANK3 protein, this antibody allows for accurate detection and analysis in various cell types, making it an ideal choice for studies in neuroscience and neurodevelopmental disorders.ANK3, also known as ankyrin-G, plays a crucial role in organizing ion channels and cell adhesion molecules in neurons, contributing to the proper functioning of the nervous system.
Mutations in the ANK3 gene have been associated with neurodevelopmental disorders such as autism spectrum disorder and bipolar disorder, highlighting the importance of studying this protein in neurobiology research. By understanding the role of ANK3 in neuronal function, researchers may gain insights into the mechanisms underlying these neurological conditions and develop potential therapeutic interventions.
Product Name:
ANK3 Rabbit Polyclonal Antibody
SKU:
CAB20299
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 833-977 of human ANK3 (NP_066267.2).
Sequence:
KMNV PETM NEVL DMSD DEVR KANA PEML SDGE YISD VEEG EDAM TGDT DKYL GPQD LKEL GDDS LPAE GYMG FSLG ARSA SLRS FSSD RSYT LNRS SYAR DSMM IEEL LVPS KEQH LTFT REFD SDSL RHYS WAAD TLDN VNLV S
Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
288
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunofluorescence analysis of SH-SY5Y cells using ANK3 Rabbit pAb (CAB20299) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
