The Anti-ALPP Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0334) is a cutting-edge tool designed for researchers studying ALPP, a key enzyme involved in bone mineralization. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting ALPP in various samples, including human tissues. Validated for use in applications such as Western blotting, the antibody binds specifically to the ALPP protein, allowing for accurate detection and analysis in a variety of research settings.ALPP, also known as alkaline phosphatase, plays a crucial role in bone mineralization and has been implicated in various diseases, including osteoporosis and certain cancers.
By targeting ALPP with this antibody, researchers can gain valuable insights into the function and regulation of this enzyme, advancing our understanding of bone metabolism and potential treatment strategies for related disorders. The Anti-ALPP Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0334) is a valuable tool for researchers in the fields of bone biology, biochemistry, and drug development.
SKU:
HDAB0334
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC686
Synonyms:
ALP; ALPI; IAP; PALP; PLAP; PLAP-1
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. One of the main sources of this enzyme is the liver, and thus, it's one of several indicators of liver injury in different clinical conditions. In pregnant women, this protein is primarily expressed in placental and endometrial tissue, however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Aug 2020]
