The Anti-Alpha Sarcoglycan (SGCA) Antibody (CAB19754) is a high-quality research tool designed for studying SGCA, a key protein involved in muscular dystrophy. This polyclonal antibody, produced in rabbits, has been validated for use in various applications, including Western blot and immunohistochemistry.SGCA is a critical component of the dystrophin-glycoprotein complex, which is essential for maintaining muscle cell membrane integrity. Mutations in the SGCA gene can lead to various types of muscular dystrophy, making it a significant target for research in this field.
This antibody specifically binds to SGCA, allowing for the detection and analysis of this protein in different tissue types. Its high reactivity with human samples makes it a valuable tool for researchers studying muscular dystrophy and related conditions.Overall, the Anti-Alpha Sarcoglycan (SGCA) Antibody (CAB19754) is an essential reagent for investigating the role of SGCA in muscle pathology and developing potential therapeutic strategies for muscular dystrophy patients.
This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6442
Clone Number:
ARC2280
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using alpha Sarcoglycan (SGCA) (SGCA) Rabbit mAb (CAB19754) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
