The Anti-Alpha-Actinin-4 Antibody (CAB3379) is a valuable tool for researchers studying the role of alpha-actinin-4 in cellular structure and function. This antibody, raised against alpha-actinin-4, a cytoskeletal protein involved in cell motility and adhesion, is highly specific and sensitive for detecting alpha-actinin-4 in human samples. Its validated use in Western blot applications allows for precise detection and analysis of alpha-actinin-4 levels in various cell types.Alpha-actinin-4 is an important regulator of actin cytoskeleton dynamics, playing a key role in maintaining cell shape and movement. Dysregulation of alpha-actinin-4 has been implicated in various diseases, including cancer and kidney disorders, making it a target of interest for researchers in these fields.
By using the Anti-Alpha-Actinin-4 Antibody, researchers can gain insights into the function of alpha-actinin-4 and its potential role in disease pathogenesis.Overall, the Anti-Alpha-Actinin-4 Antibody (CAB3379) is a valuable tool for researchers investigating the role of alpha-actinin-4 in cellular physiology and disease processes. Its high specificity and sensitivity make it a reliable choice for studies in cell biology, cancer research, and beyond.
Product Name:
α-Actinin-4 Rabbit Monoclonal Antibody
SKU:
CAB3379
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human α-Actinin-4 (O43707).
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
Purification Method:
Affinity purification
Gene ID:
81
Clone Number:
ARC1959
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using α-Actinin-4 Rabbit mAb (CAB3379) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
