The Anti-Alpha Actin 1 (ACTA1) Antibody (CAB2319) is a powerful tool for research involving ACTA1, a protein that plays a key role in muscle contraction. This polyclonal antibody, produced in rabbits, is highly specific for human samples and has been tested and validated for use in Western blot applications. By binding to the ACTA1 protein, this antibody enables researchers to detect and analyze ACTA1 in various cell types, making it an ideal reagent for studies in muscle biology and muscle-related diseases.
ACTA1, also known as alpha-actin-1, is a major component of muscle fibers and is essential for skeletal muscle function. Mutations in the ACTA1 gene have been linked to various congenital myopathies and muscle disorders, making it a key target for research in muscle development and disease. By understanding the function and regulation of ACTA1, researchers can gain insights into the mechanisms underlying muscle disorders and potentially identify new therapeutic targets for the treatment of these conditions.
Product Name:
α-Actin-1 (ACTA1) Rabbit Monoclonal Antibody
SKU:
CAB2319
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human α-Actin-1 (ACTA1) (P68133).
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause a variety of myopathies, including nemaline myopathy, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects with manifestations such as hypotonia.
Purification Method:
Affinity purification
Gene ID:
58
Clone Number:
ARC1913
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using α-Actin-1 (ACTA1) Rabbit mAb (CAB2319) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
