Alpha-2-Macroglobulin (A2M) Rabbit Monoclonal Antibody (CAB9752)
- SKU:
- CAB9752
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- A2MD
- CPAMD5
- FWP007
- S863-7
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | Alpha-2-Macroglobulin (A2M) Rabbit Monoclonal Antibody |
SKU: | CAB9752 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1200-1300 of human Alpha-2-Macroglobulin (A2M) (P01023). |
Sequence: | QAPS AEVE MTSY VLLA YLTA QPAP TSED LTSA TNIV KWIT KQQN AQGG FSST QDTV VALH ALSK YGAA TFTR TGKA AQVT IQSS GTFS SKFQ VDNN NRLL L |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | A2MD; CPAMD5; FWP007; S863-7; Alpha-2-Macroglobulin (A2M) |
Positive Sample: | Hep G2 |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 163kDa |
Observed MW: | 185kDa |
The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.
Purification Method: | Affinity purification |
Gene ID: | 2 |
Clone Number: | ARC1734 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |