The Anti-Alpha-1 Spectrin Antibody (CAB9597) is a valuable tool for research involving alpha-1 spectrin, a key protein involved in cytoskeletal structure and cell membrane stability. This polyclonal antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting.Alpha-1 spectrin plays a critical role in maintaining cell shape, supporting cell function, and facilitating intracellular transport. Dysregulation of alpha-1 spectrin has been implicated in various diseases, including hereditary spherocytosis and certain types of cancer.
By targeting the alpha-1 spectrin protein, researchers can gain insights into its function and potential therapeutic applications in these disease contexts.With its specificity and reliability, the Anti-Alpha-1 Spectrin Antibody is a valuable tool for studies in cell biology, biochemistry, and disease research. Its ability to detect and analyze alpha-1 spectrin in different cell types makes it an essential component for investigating the role of this protein in health and disease.
Product Name:
alpha 1 Spectrin Rabbit Monoclonal Antibody
SKU:
CAB9597
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 2300-2400 of human alpha 1 Spectrin (P02549).
This gene encodes a member of a family of molecular scaffold proteins that link the plasma membrane to the actin cytoskeleton and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms a component of the erythrocyte plasma membrane. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis-2, pyropoikilocytosis, and spherocytosis, type 3.
Purification Method:
Affinity purification
Gene ID:
6708
Clone Number:
ARC1650
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using alpha 1 Spectrin Rabbit mAb (CAB9597) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
