ALOX5 Rabbit Monoclonal Antibody (CAB2877)
- SKU:
- CAB2877
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- 5-LO
- 5-LOX
- 5LPG
- LOG5
- Research Area:
- Metabolism
Description
| Product Name: | ALOX5 Rabbit Monoclonal Antibody |
| SKU: | CAB2877 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human,Mouse,Rat |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human ALOX5 (P09917). |
| Sequence: | CYRW ITGD VEVV LRDG RAKL ARDD QIHI LKQH RRKE LETR QKQY RWME WNPG FPLS IDAK CHKD LPRD IQFD SEKG VDFV LNYS KAME NLFI NRFM HMFQ S |
| Tested Applications: | WB IHC-P IF/ICC ELISA |
| Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
| Synonyms: | 5-LO; 5LPG; LOG5; 5-LOX; ALOX5 |
| Positive Sample: | Raji,Rat lung |
| Conjugate: | Unconjugated |
| Cellular Localization: | Cytoplasm, Nucleus matrix, Nucleus membrane, Peripheral membrane protein. |
| Calculated MW: | 78kDa |
| Observed MW: | 78kDa |
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Purification Method: | Affinity purification |
| Gene ID: | 240 |
| Clone Number: | ARC1926 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |
 | Western blot analysis of lysates from Raji cells, using ALOX5 Rabbit mAb (CAB2877) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s. |
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