The ALDH7A1 Polyclonal Antibody (CAB20888) is an essential tool for studying ALDH7A1, an enzyme involved in the metabolism of amino acids and neurotransmitters. This antibody, generated in rabbits, has high specificity for human samples and has been validated for use in Western blot applications. By binding to the ALDH7A1 protein, researchers can easily detect and analyze its expression in various cell types, making it a valuable asset for studies in neuroscience, metabolic disorders, and neurodevelopmental diseases.ALDH7A1, also known as antiquitin, plays a crucial role in maintaining the balance of amino acid metabolism and neurotransmitter synthesis in the brain.
Mutations in the ALDH7A1 gene are associated with pyridoxine-dependent epilepsy, a rare but severe form of seizures that can be effectively managed with vitamin B6 supplementation. By understanding the function of ALDH7A1, researchers can uncover insights into the pathophysiology of neurological disorders and potentially identify targets for therapeutic intervention.
Product Name:
ALDH7A1 Monoclonal Antibody
SKU:
CAB20888
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ALDH7A1 (P49419).
The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified.
Purification Method:
Affinity purification
Gene ID:
501
Clone Number:
ARC2837
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ALDH7A1 antibody (CAB20888) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
