The AIF1/IBA1 Polyclonal Antibody (CAB19776) is a valuable tool for researchers studying AIF1/IBA1, a protein commonly used as a marker for microglia and macrophages in the nervous system. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds specifically to the AIF1/IBA1 protein, allowing for detection and analysis in various cell types, making it ideal for studies in neuroscience, neuroinflammation, and neurodegenerative diseases.AIF1/IBA1 is known for its role in the activation and regulation of microglia and macrophages in response to injury or inflammation in the central nervous system.
Its involvement in processes such as phagocytosis, cytokine release, and tissue repair makes it a key focus in research on neuroinflammation, neurodegenerative disorders, and neuroimmunology. This antibody provides researchers with a reliable tool to study the expression and function of AIF1/IBA1 in various cellular contexts, aiding in the development of therapies targeting neuroinflammatory pathways.
Product Name:
AIF1/IBA1 Rabbit Monoclonal Antibody
SKU:
CAB19776
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of mouse AIF1/IBA1 (O70200).
Enables actin filament binding activity and calcium ion binding activity. Involved in several processes, including Rac protein signal transduction; actin filament organization; and ruffle assembly. Acts upstream of or within actin filament bundle assembly. Located in several cellular components, including actin filament; phagocytic cup; and ruffle membrane. Is expressed in adrenal cortex; central nervous system; embryo mesenchyme; and retina. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human AIF1 (allograft inflammatory factor 1).
Purification Method:
Affinity purification
Gene ID:
11629
Clone Number:
ARC2301
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using AIF1/IBA1 Rabbit mAb (CAB19776) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
