The Anti-AHR Antibody (CAB4000) is a highly specific and sensitive tool for studying the aryl hydrocarbon receptor (AHR) protein in various research applications. The antibody is produced using a polyclonal method in rabbits and has been validated for use in Western blotting, immunohistochemistry, and immunofluorescence assays.The AHR protein is a transcription factor that plays a crucial role in mediating the cellular response to environmental toxins and pollutants. Activation of AHR can lead to the regulation of various genes involved in detoxification and immune response pathways.
The Anti-AHR Antibody binds specifically to the AHR protein, allowing for the detection and analysis of AHR expression levels in different cell types and tissues.Research into AHR function is essential for understanding its involvement in various diseases, including cancer, autoimmune disorders, and metabolic disorders. The Anti-AHR Antibody provides researchers with a valuable tool to explore the role of AHR in these pathologies and develop potential therapeutic strategies targeting this important regulatory protein.
Product Name:
AhR Rabbit Monoclonal Antibody
SKU:
CAB4000
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 619-848 of human AHR (NP_001612.1).
The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes.
Purification Method:
Affinity purification
Gene ID:
196
Clone Number:
ARC53212
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using AHR Rabbit mAb (CAB4000) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
