The Anti-AGTR2 Antibody (CAB3654) is a reliable tool for researchers investigating AGTR2, a key receptor involved in blood pressure regulation and cardiovascular function. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blotting applications. By targeting the AGTR2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in cardiology and hypertension research.AGTR2, also known as angiotensin II receptor type 2, plays a crucial role in modulating blood pressure and vascular tone.
Its involvement in cardiovascular physiology makes it a promising target for investigating conditions such as hypertension, heart failure, and vascular diseases. Understanding the function and regulation of AGTR2 is essential for developing targeted therapies that can effectively manage these cardiovascular disorders.Overall, the Anti-AGTR2 Antibody (CAB3654) provides researchers with a valuable tool for exploring the role of AGTR2 in cardiovascular health and disease, offering insights that could lead to the development of novel therapeutic approaches in the future.
Product Name:
AGTR2 Rabbit Monoclonal Antibody
SKU:
CAB3654
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 264-363 of human AGTR2 (P50052).
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus and in neonates, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2 infection results in down-regulation of angiotensin converting enzyme-2 (ACE2) receptors, the effects of which, triggers serious inflammatory lesions in the tissues involved, primarily in the lungs. The inflammatory reaction appears to be mediated by angiotensin II derivatives, including the angiotensin AT2 receptor which has been found to be upregulated in bronchoalveolar lavage samples from Coronavirus disease 2019 (COVID19) patients.
Purification Method:
Affinity purification
Gene ID:
186
Clone Number:
ARC2064
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using AGTR2 Rabbit mAb (CAB3654) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1min.
