AGTR2 Rabbit Monoclonal Antibody (CAB3654)
- SKU:
- CAB3654
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- AT2
- ATGR2
- MRX88
- Research Area:
- Cell Biology
Description
Product Name: | AGTR2 Rabbit Monoclonal Antibody |
SKU: | CAB3654 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 264-363 of human AGTR2 (P50052). |
Sequence: | AFII CWLP FHVL TFLD ALAW MGVI NSCE VIAV IDLA LPFA ILLG FTNS CVNP FLYC FVGN RFQQ KLRS VFRV PITW LQGK RESM SCRK SSSL REME TFVS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | AT2; ATGR2; MRX88; AGTR2 |
Positive Sample: | HeLa,293T,PC-12,HepG2,Mouse brain,Mouse kidney,Mouse uterus,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Multi-pass membrane protein. |
Calculated MW: | 41kDa |
Observed MW: | 45kDa |
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus and in neonates, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2 infection results in down-regulation of angiotensin converting enzyme-2 (ACE2) receptors, the effects of which, triggers serious inflammatory lesions in the tissues involved, primarily in the lungs. The inflammatory reaction appears to be mediated by angiotensin II derivatives, including the angiotensin AT2 receptor which has been found to be upregulated in bronchoalveolar lavage samples from Coronavirus disease 2019 (COVID19) patients.
Purification Method: | Affinity purification |
Gene ID: | 186 |
Clone Number: | ARC2064 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |