The Anti-ADAMTS13 Antibody (CAB3370) is a valuable tool for researchers studying ADAMTS13, a key enzyme involved in the regulation of blood clot formation. This antibody, produced through rabbit immunization, is highly specific to human ADAMTS13 and has been validated for use in various applications, including Western blotting.ADAMTS13 plays a crucial role in preventing excessive blood clotting by cleaving a large von Willebrand factor (VWF) protein. Dysregulation of ADAMTS13 function has been implicated in various thrombotic disorders, making it a promising target for therapeutic interventions.
The Anti-ADAMTS13 Antibody enables researchers to detect and quantify ADAMTS13 levels in biological samples, leading to a better understanding of its role in health and disease.By utilizing the Anti-ADAMTS13 Antibody in their experiments, researchers can unravel the mechanisms underlying thrombotic diseases and potentially identify new strategies for preventing and treating these conditions. Its high specificity and sensitivity make it an essential tool for studies focused on ADAMTS13 function and its implications in various pathological conditions.
Product Name:
ADAMTS13 Rabbit Monoclonal Antibody
SKU:
CAB3370
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ADAMTS13 (Q76LX8).
Cell surface, Endoplasmic reticulum lumen, Extracellular space
Calculated MW:
154kDa
Observed MW:
190kDa
This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
11093
Clone Number:
ARC1957
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using ADAMTS13 Rabbit mAb (CAB3370) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
